Biomolecules - NEET Previous Year Questions with Complete Solutions-eSaral

Enzymes is the single most important topic in Biomolecules for NEET. It has produced the highest number of questions over the last 12 years. Focus specifically on enzyme properties, factors affecting enzyme activity (temperature, pH, substrate concentration), competitive vs non-competitive inhibition, and the role of cofactors, coenzymes, and prosthetic groups.

Biomolecules is considered moderate in difficulty. The chapter is factual and concept-based rather than calculation-heavy. Most students find enzyme kinetics (Km, Vmax, inhibition types) and nucleic acid structure the trickiest parts. Thorough NCERT reading combined with solving 10 years of PYQs makes this chapter very manageable within 2–3 weeks of focused study.

Biomolecules typically contributes 3–5 questions in NEET-UG each year, totalling 12–20 marks. Based on papers from 2017 to 2024, the average is approximately 4 questions per paper. Enzymes and protein structure are the most consistently tested sub-topics, making them the highest-priority areas for revision.

To score full marks from Biomolecules, follow this plan: read NCERT Class 12 Biology Chapter 9 at least three times, draw all diagrams from memory, solve 10 years of PYQs with solutions, create a one-page quick-revision sheet of all enzyme terms and bond types, and revise within 48 hours before the exam. This strategy — used by eSaral's Kota-quality online batches — reliably secures 16–20 marks from this chapter.

Several bond types are regularly tested: peptide bonds (between amino acids in proteins), glycosidic bonds (between monosaccharides in polysaccharides), phosphodiester bonds (between nucleotides in DNA/RNA), and hydrogen bonds (between base pairs in DNA and in protein secondary structure). Know the name, location, and how each bond is formed and broken

Yes, NCERT is sufficient for Biomolecules in NEET. Every question from this chapter in past NEET papers can be answered using Class 12 NCERT Biology alone. Read every line, study all diagrams — especially the enzyme activity graphs and DNA structure diagram — and note every example given in the text. Supplementary books are not needed for this chapter.